Francesco Matano was born in Santa Maria Capua Vetere in 1989 to an Italian father and an American mother.
He grew up in Carinola but studied as a teenager in the United States, where he graduated from Cranston High School East in Rhode Island.
In 2011, he participated in the program Ti lascio una canzone by Antonella Clerici, conducting short interviews with the cast.
In 2015 he appeared on television as an envoy of Le Iene presentano: Scherzi a parte, planning jokes on victims Paolo Brosio and Ruffini.
That same year he starred alongside Claudio Bisio in the film What a Beautiful Surprise, directed by Alessandro Genovesi.
On 4 February 2018, he participated as a competitor along with Iva Zanicchi on the special edition of Guess My Age - Indovina l'età led by Enrico Papi on the Italian channel TV8.