[2][3] The Frank R. Lillie House stands in Chicago's Hyde Park neighborhood, on the east side of the University of Chicago campus at the southeast corner of South Kenwood Avenue and East 58th Street.

It is characterized by flat surfaces with diamond-shaped brickwork, unusually shaped brick corner quoining, and a variety of roof treatments.

The interior has retained many of its original finishes despite conversion of the space to academic functions by the university.

Lillie was also an important figure in the science organizations, garnering significant financial support for the Woods Hole Oceanographic Institute (where he had spent a summer as a student), and helping it become a major scientific research institute.

[3] Lillie bequeathed his house to the University of Chicago, reserving a life interest for his wife.