Francis Hugh Ruddle (1929–2013) was an American cell and developmental biologist who was the Sterling Professor at Yale University.

[6] Leaving high school early, Frank became a member of the United States Air Force in 1946 and fought for the country up until the year 1949.

[8][9][10] Ruddle started his research and experimentation at Yale, and his work in the lab contributed to the development of the Human Genome Project.

[8] It was during the year of 1981 that Ruddle and his team's research was first published, announcing that they had created the first ever transgenic mouse, by completely changing the arrangement of their genes.

[8][9][10] The scientists were able to successfully transfer genes from two viruses known as Herpes simplex and SV-40, into new fertilized mouse eggs, which were then inserted into female mice.