He served as the head football coach at Boston College from 2009 to 2012, compiling a record of 22 wins and 29 losses.

[2] He was the subject of one of Joe Paterno's notable early quotes: the Nittany Lions' coach said of Spaziani, "Don't get the idea that I like him because he's Italian.

Spaziani coached in the Canadian Football League (CFL) as a defensive coordinator for the Winnipeg Blue Bombers (two seasons) and Calgary Stampeders (three years).

In 1997, Spaziani left the Calgary Stampeders for a position as running backs coach for the Boston College Eagles.

[4] Coached by Spaziani, Boston College's Mike Cloud was a consensus first-team All-America selection and a finalist for the 1998 Doak Walker Award.

[6] On January 8, 2016, Spanziani was hired to be the defensive coordinator for the New Mexico State Aggies football team.