Frank E. Thompson (July 2, 1895 – June 27, 1940) was an American professional baseball player and manager.

He appeared in Major League Baseball (MLB) as a third baseman for the St. Louis Browns in 1920.

He played professionally from 1914 through 1924, appearing in over 800 minor-league games.

[1] He then served as a minor-league manager during 1925 and 1926.

This biographical article relating to an American baseball third baseman is a stub.