Frank Wilkinson Crowe (July 2, 1919 – April 29, 1987) was an American physician, who practiced Dermatology in Boise, Idaho.
He was a world-renowned authority for the Crowe sign or Crowe's sign in neurofibromatosis which is the presence of axillary (armpit) freckling in people with neurofibromatosis type I (von Recklinghausen's disease).
These freckles occur in up to 30% of people with the disease and their presence is one of seven diagnostic criteria for neurofibromatosis.
In 1956 Crowe et al. recognised the autosomal dominant heredity of neurofibromatosis and the use of 6 or more café au lait spots to diagnose the condition.
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