Franken Fran (フランケン・ふらん, Furanken Furan) is a Japanese manga series written and illustrated by Katsuhisa Kigitsu.

Her life is rather uneventful besides scientific research work until various medical cases begin falling into her lap, ranging from resurrection to aesthetic surgery.

There is a fair amount of dark humor with nearly each story ending with Fran either creating a gruesome monstrosity or bringing some kind of misfortune upon her patients, though usually she is seemingly content with the results due to her extreme life-preserving mindset.

She is fitted with two sizable bolts upon her temples and marred with faint stitches, giving her a distinctly inhuman appearance.

While most often aloof, she has shown that she is aware that her actions ruin lives, and is very capable of using her talents to punish others, should they seriously offend her or hurt others, such is the case with a group of spies sent to steal her and Dr. Amatsuka's secrets and research.

As such, she is notably violent, though bound to a humane battle etiquette and creed: "to murder while causing as little suffering as possible" and "rather a painless death than a painful life."

Wielding a huge guillotine blade in her right arm and a sharp sword in her left, she also appears to have needles on the ends of her fingertips which allow her to inject viruses into her victims.

Gavrill has the appearance of a woman in her twenties or late teens with wild, unkempt violet hair, a line of stitching going across the bridge of her nose, and black leather clothing adorned with various arm and leg braces she presumably wears as accessories.

She is what Fran calls a "Transformer", the entirety of her skeletal, muscular, organ, and nervous systems being partitioned into many smaller divisions so that she can consciously control them, granting her shapeshifting capabilities as well as a formidable regenerative healing factor.

In Franken Fran Frantic, it is implied that Gavrill had been going to Dr. Amatsuka for her body tunings due to her legitimately caring for his company and well-being, despite her vulgar and insulting language towards him.

During the second World War, Naomitsu worked for the Biochemistry Division, earning fame and the moniker of "Devil of Biology" and "Spider's Thread" due to the nature of his experiments.

After isolating Gavrill on an island, Rumiko was cloned and genetically coded to undergo a form of mitosis, creating an endless force.

Dr. Naomitsu Madaraki, the surgeon in charge at the time, modified Adorea into her present condition so she could reclaim her organs with interest.

The series is licensed in English by Seven Seas Entertainment, who announced their plans to release it in four 2-in-1 omnibus volumes starting in February 2016.