The series is notable for its violence, fan service, and the use of milk-like vital energy coming from women's breasts (referred to as Soma) as a central plot device.

An OVA adaptation titled The Qwaser of Stigmata: Portrait of the Empress (聖痕のクェイサー: 女帝の肖像, Seikon no Kweisā: Jotei no Shōzō) was also produced and released on DVD with the manga series volume 10.

Mafuyu and Tomo's lives take a drastic turn when they nurse the silver-haired Russian-born Alexander "Sasha" Nikolaevich Hell back to health upon encountering him unconscious one day during their commute home.

[8] Tokyopop licensed the series for the North American market and published the first four volumes; however, since resuming business in December 2012, the title has not been listed in their online catalog.

The first season was followed by a single episode OVA with the title The Qwaser of Stigmata: Portrait of the Empress (聖痕のクェイサー: 女帝の肖像, Seikon no Kweisā: Jotei no Shōzō) that was released on DVD with the manga series volume 10.

Lantis has taken the opportunity presented by the Seikon no Qwaser anime to produce an Internet radio show starring Aki Toyosaki as Tomo Yamanobe and Yōko Hikasa as Hana Katsuragi[10] alongside commercially releasing the five theme songs as indicated in the table below.