The course then continues along Reuterweg and Bremer Strasse in a northerly direction as far as the Westend Campus at the University of Frankfurt, before returning to Opernplatz via Eschersheimer Landstrasse and the Bockenheimer Anlage.

Continuing into Junghofstrasse the course heads into Roßmarkt then past the Frankfurt Stock Exchange, the Eschenheimer Tor and the Friedberger Tor before turning south towards and over the Alte Brücke over the River Main which brings the athletes into the suburb of Sachsenhausen on the southern side of the river.

The only notable ascent on the course occurs at the bridge back over the Main in Schwanheim, and the participants continue westwards to the Bolangaropalast in Hoechst, Frankfurt's most westerly suburb.

The course then continues along Taunusstrasse [de] (English: Taunus Street) and Kaiserstrasse past the Taunusanlage and then the Roßmarkt is negotiated for the second time to Eschenheim.

The last three kilometres go back past the Alter Oper and via the Platz der Republik into the Festhalle, where athletes run the last few metres on a specially-laid red carpet before crossing the finishing line.