Composer-violinist Louis Spohr was the second principal conductor (1817–1819) of the Museumsorchester; his successors included Clemens Krauss, William Steinberg, Franz Konwitschny, Georg Solti, Christoph von Dohnányi, and Michael Gielen.
Richard Strauss' large-scale tone-poems Ein Heldenleben and Also sprach Zarathustra were both premiered by the Frankfurter Opern- und Museumsorchester.
In the 2005/2006 and 2006/2007 seasons, the Museumsorchester was voted one of the three top German opera orchestras in the country, selected by the leading operatic magazines in Germany.
For the 2007/2008 season, the noted German periodical Die Deutsche Bühne voted the Oper Frankfurt the best opera house in Germany.
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