Franklin Harford Spence (February 22, 1883- January 16, 1943) was an Ontario pharmacist and political figure.
He represented Fort William in the Legislative Assembly of Ontario from 1923 to 1934 and from 1937 to 1943 as a Conservative member.
He defeated UFO-Labor cabinet minister Harry (Henry) Mills in the 1923 election, was re-elected in December 1926 and again in October 1929, chiefly because of the popularity of Ontario premier Howard Ferguson - "A vote for Spence is a vote for Ferguson," he advertised.
He played a subordinate role to other Conservative party heavyweights from Northern Ontario, Donald McDonald Hogarth and Francis Henry Keefer.
He was the son of James Edward Spence and was educated in Prince Albert, Saskatchewan and at Toronto University.