On August 31, 2017, the Astros traded Pérez to the Detroit Tigers, along with Jake Rogers and Daz Cameron, for Justin Verlander.
[16] In 2022, he returned to action, making 10 starts for the rookie–level Florida Complex League Tigers, and struggling to a 9.59 ERA with 18 strikeouts in 25+1⁄3 innings pitched.
[17] In 2023, he made 10 appearances split between the FCL Tigers and Lakeland, posting a cumulative 6.89 ERA with 7 strikeouts in 15+2⁄3 innings of work.
[18] On February 9, 2024, Pérez signed with the Gary SouthShore RailCats of the American Association of Professional Baseball.
[19] In 15 games (4 starts) for Gary, he struggled to an 0–4 record and 9.45 ERA with more walks (24) than strikeouts (15) across 33+1⁄3 innings pitched.