Franquelis Antonio Osoria (born September 12, 1981) is a retired Major League Baseball pitcher.

Osoria made his Major League Baseball debut with the Los Angeles Dodgers on June 7, 2005.

On November 30, 2008, he signed a minor league contract with the Kansas City Royals.

Like fellow reliever Antonio Alfonseca, Osoria has an extra digit on his throwing hand.

This biographical article relating to a Dominican Republic baseball pitcher is a stub.