Van den Wyngaerde became an apprentice of the Rubens collaborator Paulus Pontius (1603–1658) when he was about 14 years old.

Lacking sufficient funds, the dean of the guild loaned him part of the membership fee.

Van den Wyngaerde's prints after his own original designs include etchings, engravings and plates in which both techniques are used.

In addition to publishing his own work and that of his contemporaries, van den Wyngaerde reused old plates by well-established artists to which he added his name and then reissued.

He published seven plates by Jusepe de Ribera, a Spanish artist working in Naples.