Henry Frazier Reams Sr. (January 15, 1897 – September 15, 1971) was an American lawyer and politician of the United States Democratic Party from Toledo, Ohio.

During this time, Reams led a campaign to clean up Toledo and rid the city of the many gangsters and bootleggers who resided and did business there.

Reams was most well known for leading the prosecution of Thomas "Yonnie" Licavoli, who controlled bootlegging and illegal gambling operations in Detroit, Michigan and Toledo.

A grand jury convened by County Prosecutor Reams had issued indictments of two brothers of Toledo Mayor Addison Q. Thacher, a Republican, on charges related to welfare payments and bank closings.

In 1936, Reams sought the Democratic nomination for the office of Ohio Attorney General, but he lost to Herbert S. Duffy.

In 1944, Reams sought the Democratic nomination for Governor of Ohio, but he placed fourth in the contest that was won by Frank Lausche.

In 1950, Reams, according to his New York Times obituary,[1] split with the Democratic organization in Toledo and was elected to the U.S. House of Representatives as an independent.

However, in 1954, Reams was unsuccessful in his bid for a third term in Congress, losing his seat to a fellow Democrat, Thomas Ludlow Ashley.