The father was a painter and the mother a porter and piano teacher, both coming from Graglia, his great passion for music appeared at a very young age.

After the war, Buscaglione returned to Turin and went to live in Via Eusebio Bava 26 bis and resumed working as a musician for various bands.

At 38 years of age, he was killed in a car accident when his lilac Ford Thunderbird collided with a truck Lancia Esatau in the early hours before dawn in Rome.

Alongside his legacy, in songs and movies, Buscaglione deserves mention for having encouraged musicians and singers from the newer generation (the one influenced by the earliest forms of rock and roll) to stand up against the conservative producers and discographers of the time, demanding recognition for their art and their style.

In this role, he proved instrumental in the rise of the "yellers" scene which from the early 60s started to revolutionize the Italian popular music panorama.