[5] Before the nationally televised CNN town hall he criticized President Donald Trump for not saying guns are a problem in a White House listening session, saying "My daughter was hunted last week" and "I am enraged".

[12][13] Guttenberg noted that guns were prohibited by the Secret Service at the NRA convention in Dallas when vice president Mike Pence is scheduled to speak, and criticized the decision as hypocritical.

I thought giving everyone a gun was to enhance safety.In early March 2018 he traveled to Washington to speak at a US Senate hearing[15][16] about taking steps to prevent further violence.

This will not be temporary.Javier Manjarres, a Republican primary election candidate for Florida's 22nd congressional district, wrote on social media in July 2018, "C'mon Fred...stop exploiting her death in the name of some political agenda...your daughter was shot by some lunatic who had an AR-15, not by the gun itself.

[21] Guttenberg responded that he would do everything possible to make sure that Manjarres would not "sniff the halls of Congress", and that "If you call honesty around gun safety exploitation, then you clearly have a political agenda.

[32] After Robb Elementary School shooting in 2022, Guttenberg called for politicians to enact stricter gun control, and expressed support for the families of the victims.

[34][35] In 2024, Guttenberg disavowed gun violence advocacy group March for Our Lives, claiming that their support for pro-Palestine college protests in the Israel–Hamas war was antisemitic.

[36] He had also previously stated that he would support a pro-Israel Republican over an anti-Israel Democrat in an election, and that he was in favor of Governor Ron DeSantis's moves to ban Students for Justice in Palestine chapters from Florida universities.

[37] In May 2018, Guttenberg and another parent whose child was killed in the massacre filed lawsuits against American Outdoor Brands, a company that makes the AR-15 rifle, and Sunrise Tactical Supply, a store that sold the weapon to the shooter, as being "complicit in the attack" that resulted in 17 deaths.