Fred Isabella (August 3, 1917 – November 28, 2007) was an American dentist and politician.
Born in Mechanicville, New York, Isabella served in the United States Army during World War II.
He went to the Albany College of Pharmacy and Health Sciences and the University at Buffalo School of Dental Medicine.
He was a dentist in Schenectady, New York; Isabella and his wife also owned a pharmacy.
From 1958 to 1974, Isabella served on the Schenectady City Council and was a Democrat.