Growing up in Nappanee, Indiana, Neher was 12 years old when he was paid $2.00 for doing a drawing of a woman hanging clothes with a new type of clothespin.

Neher succeeded in selling a cartoon to the popular humor magazine Judge before he graduated from high school in 1922.

Neher drew Goofey Movies for five years, along with gag cartoons for 42 magazines, including Collier's and The New Yorker, when the Bell Syndicate launched Life's Like That on October 1, 1934.

Neher stopped doing the Life's Like That Sunday half-page in October 1972,[2] and he retired five years later, devoting his energy to playing golf, raising roses and growing tomatoes.

He donated his Life's Like That cartoon originals, scrapbooks, published books, magazines and correspondence to the University of Colorado Library Archives (where they fill 36 linear feet).