Frederick of Zweibrücken-Vohenstrauss-Parkstein (German: Friedrich) (11 April 1557 – 17 December 1597) was the Duke of Vohenstrauss-Parkstein from 1569 until 1597.

Frederick was born in Meisenheim in 1557 as the fourth son of Wolfgang, Count Palatine of Zweibrücken.

After his father's death in 1569, and still a minor, his guardianship was assumed by his older brother Philipp Ludwig until 1581, when he was obtain his own domains: the districts of Flossenbürg, Floß and Vohenstrauss with the Parkstein-Weiden enclave.

On 21 February 1598, Frederick was buried with his sons in the family crypt in St. Martin in Lauingen.

Frederick married on 26 February 1587 with Katharina Sophie (7 August 1561 – 10 May 1608), daughter of Duke Henry XI of Legnica.