He served as bishop of the Diocese of Sault Sainte Marie-Marquette in the Upper Peninsula of Michigan from 1899 to 1922.

Frederick Eis was born in Arbach, then in the Rhine Province of the Kingdom of Prussia, part of the German Empire (present day Germany).

[1] Eis was ordained a priest by Bishop Ignatius Mrak on October 30, 1870, for the Diocese of Sault Sainte Marie and Marquette.

[3][1] On June 7, 1899, Eis was appointed the fourth bishop of the Diocese of Sault Sainte Marie and Marquette by Pope Leo XIII.

[6] During Eis' 23-year tenure as bishop, he led the diocese through the nationalist controversies within the American Catholic community, and founded several charitable institutions and hospitals.