Modern and contemporary artwork in the Frederick R. Weisman collection are displayed in a "living with art—house museum" context, with guided public tours by appointment with the foundation.
From 1960 to 1964, Marcia Weisman hosted monthly proselytizing classes for novice collectors, taught by Irving Blum and Walter Hopps, whose Ferus Gallery in West Hollywood was the first to show Frank Stella, Ellsworth Kelly, and Roy Lichtenstein in Los Angeles.
David Hockney portrayed them in a 1968 double portrait called American Collectors (Fred and Marcia Weisman), now in the Art Institute of Chicago, that has become one of his most famous works.
The Weisman Foundation estate, located in the Holmby Hills area of western Los Angeles, consists of two landmark buildings in spacious gardens.
The main structure is the Mediterranean Revival style two-story residence designed in the late 1920s by Los Angeles architect Gordon B. Kaufmann.
The holdings in postwar art include works by Giacometti, Isamu Noguchi, Alexander Calder, Robert Rauschenberg, and Jasper Johns; Abstract Expressionist paintings by de Kooning, Sam Francis, Clyfford Still, and Mark Rothko; Color-Field paintings by Helen Frankenthaler, Morris Louis, and Kenneth Noland; and Pop Art by Andy Warhol, Roy Lichtenstein, Claes Oldenburg, and James Rosenquist.