Frederick Skene (July 25, 1874 – August 22, 1943) was an American civil engineer and politician from New York.

He was New York State Engineer and Surveyor from 1907 to 1908, elected on the Democratic Party/Independence League fusion ticket in 1906.

During and after his tenure, suspicions of graft and fraudulent contracts for roadworks came up.

Skene was acquitted by the jury, and his accuser Charles H. O'Neil, who had been his Confidential Assistant, was arrested on charges of perjury.

He was dean of the school of technology of City College of New York until January 1940 when he retired.