She was the fourth French vessel named after the 18th Century admiral count Toussaint-Guillaume Picquet de la Motte.

[3] On 22 August 2007, she took custody of the Danish freighter Danica White which had been captured by pirates on 3 June.

She left Brest on 9 November 2011 for active duty in the Indian Ocean and was refuelled by the US replenishment ship USNS Patuxent on 10 January 2012.

[4] On 22 January she passed through the Straits of Hormuz with the British frigate HMS Argyll and a US battlegroup centred on the aircraft carrier USS Abraham Lincoln.

[6] In March 2016, La Motte-Picquet shadowed the Russian destroyer Vice-Admiral Kulakov, an oiler and a tugboat as it passed near French waters.