Fridolin Sulser (2 December 1926 – 3 January 2016) was a Swiss-American pharmacologist who specialized in the treatment of mental disorders.
Before having been appointed assistant professor at the University of Bern, he served a mandatory 2-year term officer in the Swiss Army.
He moved with his family to the United States in the fall of 1958, having obtained a post-doctoral fellowship in neuropsychopharmacology at the National Institutes of Health in Bethesda, M.D, funded by Swiss Academy.
In 1965 he joined the Vanderbilt University Medical School Faculty as professor and Director of the Pharmacology Research Center.
He gained recognition for an early hypothesis of the mechanism of action of antidepressant drugs, suggesting in 1975, together with Jerzy Vetulani, that downregulation of beta-adrenergic receptors is responsible for their effects.