[1] Nake had his first exhibition at Galerie Wendelin Niedlich in Stuttgart in November, 1965 alongside the artist Georg Nees.

The bulk were done as China ink on paper graphics, carried out by a flatbed high precision plotter called the Zuse Graphomat Z64.

[4][5][6] Nake participated in the important group shows of the 1960s, such as, most prominently, Cybernetic Serendipity (London, UK, 1968),[7][8] Tendencies 4: Computers and Visual Research (Zagreb, Yugoslavia, 1968),[9][10] Ricerca e Progettazione.

The note sparked a lively controversial debate among those who had meanwhile started to build an active community of artists, writers, musicians, and designers in the digital domain.

His book Ästhetik als Informationsverarbeitung (1974) is one of the first to study connections between aesthetics, computing, and information theory, which has become important to the transdisciplinary area of digital media.