He was considered an excellent diagnostician, dedicated to histological research in the field of internal medicine.
His primary focus dealt with diseases of the bronchi and mediastinum as well as blood and metabolic disorders.
[1] With Paul Langerhans (1847-1888), he investigated the "intravital storage" of cinnabar injected intravenously into laboratory animals.
They also noted the accumulation of cinnabar in fixed cells of the bone marrow, in the connective tissue of the liver and in the capillary system.
These findings were part of the research that later spawned Ludwig Aschoff’s idea of the reticuloendothelial system.