Friedrich von Wirsberg was born in Glashütten, Bavaria on November 16, 1507.

[1] On April 15, 1558, Melchior Zobel von Giebelstadt, Prince-Bishop of Würzburg, was assassinated by the forces of Wilhelm von Grumbach.

[2] The cathedral chapter of Würzburg Cathedral elected Friedrich von Wirsberg as Zobel's successor on April 27, 1558.

[2] Von Grumbach, along with Albert Alcibiades, Margrave of Brandenburg-Kulmbach, sought refuge in the Kingdom of France.

[2] In 1560, von Wirsberg expelled all Jews from the Prince-Bishopric of Würzburg.