The series stars Harold Perrineau, Catalina Sandino Moreno, Eion Bailey, David Alpay, Elizabeth Saunders, Scott McCord, and Ricky He in main roles.

The unwilling residents strive to stay alive while plagued by terrifying nocturnal creatures from the surrounding forest as they search for secrets hidden within the town and beyond in the hope of finding a way out.

The series centers around Boyd Stevens (Perrineau), the self-appointed sheriff and de-facto mayor, and the Matthews family, new arrivals to the town who soon discover that they are trapped along with the other existing residents, and must work together to stay alive and find a way to escape.

On June 7, 2018, YouTube Red announced the development of the John Griffin–created series as part of an overall deal between production companies Midnight Radio and the Russo brothers' AGBO.

[4][5][6] In July, Shaun Majumder, Elizabeth Saunders, Avery Konrad, Hannah Cheramy, Ricky He, Simon Webster, Chloe Van Landschoot and Pegah Gahfoori joined the cast.

The website's critical consensus reads, "Ably anchored by Harold Perrineau, From is an intriguing journey toward a mysterious destination.