Built in the early 1960s, the street was named after Edward Charles Frome, who was Surveyor General of South Australia for most of the 1840s.

[2] In the 1970s the state government halted the development, so the street only extends part way across the city centre.

[4] In 2014, the southern part of Frome Street was modified to create separated bike lanes between the parallel car parking and the footpath.

These lanes connect with minor laneways to the south and a path across the Adelaide Parklands as the Frome Street Bikeway.

[5] In 2017–18, the bikeway was extended to Grenfell Street (completed February 2018), and part of what had already been built was removed and relaid to match.