This was the second television anthology Western series, after Death Valley Days, and as such had no regular cast members, except that each episode was introduced and narrated by Walter Coy.
Walter Coy served as the narrator each week to introduce the story, and following the Death Valley Days format, he also occasionally appeared as a guest actor.
[4] Guest stars included Jack Kelly, Leo Gordon, Tom Tryon, Phyllis Coates, Jack Elam, John Dehner, Denver Pyle, Strother Martin, James Best, Chuck Connors, Rhodes Reason, Alan Hale Jr., Mike Connors, Robert Vaughn, Richard Crenna, Claude Akins, Coleen Gray, Richard Boone, Catherine McLeod, Tommy Kirk and Gloria Talbott, among others.
The New York Times called the premier episode "a superior adventure yarn" and wrote that "with the other recent arrivals, Gunsmoke and the Wyatt Earp series, Frontier should provide Western fans with enough action to carry them nicely through the winter".
[6] TV Guide added to the positive reviews by pointing out that Frontier "eschews the exploits of guntoting marshals", instead concentrating on the "ordinary people who helped settle the West", calling the show "uniformly excellent" and "absorbing".