Frozen tissue array

Paraffin tissue array was developed during late years in the 1980s; this array can help scientists high throughput analyze gene and protein expressions in multiple tissue samples, especially analyze different protein levels with antibodies by immunohistochemistry.

Buffered formalin solutions cross link proteins and nucleic acids when they are used for fix tissues.

Scientists who have been developing antibodies for therapeutic purpose all need their preliminary results from frozen tissues to get approval from FDA.

Sections from this block are cut using a cryostat, mounted on a microscope slide and then analyzed by any method of standard histological analysis.

Tests commonly employed in frozen tissue array include immunohistochemistry, and in situ hybridization.