[3] Throughout the manga and anime, Fujiko serves as Lupin's on-and-off love interest and rival, with the former exploiting the latter's weakness for women for personal gain.

As the Lupin III series was made to be published in a magazine targeted at adults, Fujiko Mine was created to add a female presence.

Fujiko is also known to provide law enforcement (particularly Lupin's nemesis Inspector Zenigata) with information and assistance in order to gain her own freedom.

Later, she's revealed superb martial arts skills, capable of rendering an attacker twice her weight unconscious with a single blow.

Like the other members of Lupin's team, she is able to pilot virtually any land, sea, and air vehicle, with her personal preference being a conventional Kawasaki motorcycle.

[11] Daisuke Jigen despises Fujiko and sees her showing up as a sign of rough times ahead, although despite this, in the original manga he was still one of her suitors.

Mine, has been known to work on capers with Fujiko independent of the other gang members, but can be equally distrustful of her when he thinks she is manipulating Lupin.

Still, in the Lupin the Third Part II anime Jigen and Goemon are seen working together numerous times with Fujiko, trusting their lives on her, and vice versa, with them having a sibling rivalry of sorts.

Fujiko usually dresses in the height of fashion, with formal gowns and fine jewelry her trademark; when informal, she typically wears outfits that accentuate her robust figure.

Fujiko's favorite pastimes appear to be shopping, attending social functions, disco dancing, horseback riding, and dating wealthy gentlemen.

Fujiko made her first appearance in the third chapter of the original manga, "Death Blues" (死んでゆくブルース, Shinde Yuku Burūsu),[14] with her creation predating those of Jigen and Goemon.

She initially appears as a con woman attempting to worm her way into the fortune of a rich family, whose heir has hired Lupin as security.

[19] The 2011 TV special Blood Seal – Eternal Mermaid marked the first appearance of Miyuki Sawashiro as the character and she continues to voice Fujiko Mine to this day.

[21] Due to a lack of localization credits on any known prints, Fujiko's English voice actress in the 1979 Toho dub of The Mystery of Mamo, where the character's name was changed to "Margo", remains unknown.

[31] A 2015 Charapedia poll, which asked fans to list their favourite "cool" women in anime, had Fujiko placed seventeenth.

"[35] Crunchyroll's Chad Landon Smith wrote that "mysterious" is Fujiko's defining character trait and that being "born of the femme fatale stereotype, her intentions and motivations are never meant to be clear.

[37] In his review of the first anime, Chris Beveridge of The Fandom Post enjoyed that while Fujiko has a bit of a "sexpot feel about her here, she's the one that's the most conniving here and does it all with a wicked grin and a smile.

"[40] Of Meisa Kuroki's performance in the 2014 live-action film, Matt Schley of Otaku USA commented that the actress comes as close to Fujiko "as any real human female can, I suppose.

In the manga Azumanga Daioh by Kiyohiko Azuma, Tomo Takino is a fan of the Lupin III series and admires Fujiko.