[2] The fulvous harvest mouse has a widespread distribution with a range extending from Honduras, Guatemala and El Salvador northwards through Mexico to the southwestern United States, where it is present in Arizona, Texas, Oklahoma, Kansas, Missouri, Arkansas, and Mississippi.

Other adaptations to winter include a lengthening of the animal's hair and a possible daily reduction of its body temperature during sleep in the daytime.

[3] A nest is built in vegetation just off the ground and consists of a ball of grasses and sedges about 75 mm (3.0 in) in diameter.

Predators of this mouse include barn owls (Tyto alba) and red-tailed hawks (Buteo jamaicensis).

The young are blind, naked, and helpless at birth, their eyes open between the ninth and 12th days and weaning takes place between the 13th and 16th.