[1] The large altarpiece was commissioned by the provost of Prato, Geminiano Inghirami, a patron of the arts who also called Donatello and Michelozzo to work in the cathedral.

The pomegranate cloth is also visible in the funerary monument of Geminiano Inghirami, once in the church of San Francesco, attributed to Pasquino da Montepulciano (1460).

The mourner's faces show that Lippi had studied Giotto's work in the Bardi Chapel, as some gestures are very similar, such as that of the monks kissing the saint's feet or the one raising his hands.

In the foreground is Inghirami kneeling, with a crippled youth in front of him who points at Jerome's body (a trick to avoid that the donor's red garments could distract the observer).

The upper part of the panel, aside from rocky mountains with three secondary scenes (Adoration of the Child and two episodes of the saint's life), is occupied by angels, perhaps executed by Fra' Diamante or another collaborator.