[4] This species is ranked as being of Least Concern by the International Union for Conservation of Nature (IUCN), and has been found at between 27 and 459 metres (89 and 1,506 feet) above sea level.

[1] In an integrated field study on Mayotte, 35 specimens of Furcifer polleni were found in a range of habitats at altitudes of up to 459 metres (1,506 ft).

These included (in approximately equal numbers) pristine forests, degraded woodlands, plantations and scrubby dry vegetation.

This does not seem to have had much influence on the population size and was in contrast to the endemic chameleon species on Grand Comoro, Furcifer cephalolepis, which suffered a much heavier trade.

The study concluded that the population of the Mayotte chameleon is stable, and that despite the small area in which it occurs, it is likely to survive due to its ability to live in non-natural habitats.