Fuse was acquired by SiTV Media in 2014 and, after merging with the Latino-oriented NuvoTV in 2015, would shift its focus to general entertainment and lifestyle programming targeting multicultural young adults.

[1] With a number of cable operators discontinuing their carriage in the years since, the channel currently has an availability of around 34 million pay television households as of 2022.

[2] The channel originally launched on July 1, 1994, as MuchMusic USA; it was founded as a joint venture between Rainbow Media (currently known as AMC Networks), a division of New York–based Cablevision and Toronto-based CHUM Limited.

[citation needed] Beginning in 1996, Rainbow began an effort to add U.S-produced original programming and music video blocks to the network.

[6] By 2001, MuchMusic USA began to diverge from its Canadian parent; it introduced a new logo identifying itself as MMUSA, and began to air its own original programming and music video blocks, often featuring user-submitted videos; the network's new direction centered around viewer interactivity via the Internet, with the "mmusa.tv" website being the focal point of the interaction.

[20] In the fall of 2012, Fuse refocused itself with a new on-air branding campaign[21] created by design agency LoyalKaspar, with its website now featuring trending music news stories.

In March 2013, anonymous sources leaked news that MSG was planning to sell all or part of Fuse, as the network had been struggling, and was facing growing competition from digital outlets.

[30][31] In addition, the newly rebranded parent company, Fuse Media, announced the launch of a new music channel focusing on "up-and-coming, young, diverse talent".

[34][35] In addition to new series such as Transcendent, which documents the lives of transgender women at AsiaSF Cabaret & Restaurant in San Francisco, and Revealed, which features music videos, interviews, and behind-the-scenes footage of artists at work, Fuse announced a multi-year partnership with comedian Gabriel Iglesias for additional new programming and comedy specials.

[43] On November 19, 2020, current Fuse Media CEO Miguel Roggero and a "Latino-led management group" announced that they have acquired majority interest in the company.

In addition, Combate Global's library content would begin streaming on the company's El Rey Rebel FAST channel.