Matsui has been making her works based on her psychoanalysis results, putting heavy weight on her feelings and interests in violence, experience of loss, repression, stress, and trauma.
Through the process of self-investigation, she found her works universal to all living beings—life and death, sex, self-love, self-mutilation, self and the other, this world and the next, desire and passions.
For example, her painting "Insane Woman under the Cherry Tree" (2006) is inspired by "Ogress under Willow Tree,” a painting by Soga Shohaku (1730–1781), the iconoclastic Edo-period painter, who was influenced by the art of the Muromachi Era painter Soga Jasoku (d. 1483).
[3] “I quickly escaped outside, but I was so shocked by what happened in the Tohoku area that I couldn’t paint for two months.
In 2011, she held an exhibition "Fuyuko Matsui: Becoming Friends with All the Children in the World" at Yokohama Museum of Art, Kanagawa, Japan.
In 2010, she participated in the "Koizumi Yakumo-The Secret of Lafcadio Hearn" group exhibition in Contemporary Art Museum in Kumamoto.
In 2012, her works entered the group exhibition "Phantoms of Asia" in Asian Art Museum of San Francisco.