[6][7] The plot is based on the movie, in which a group of highly trained guinea pigs (Darwin, Blaster, and Juarez) fight against Leonard Saber, an evil billionaire and his robotic "household appliances" army.

The game also interjects several new locations including the appliance production centre and some sewers not seen in the movie, and Saber's partner "Yanshu" talks to Darwin several times throughout the third and fourth acts.

In addition, the game also ends differently, Darwin finds Speckles in a giant satellite dish rather than at an appliance store, and the latter does not have a change of heart and does not stop his evil plan.

[9] The most notable difference among the various platforms on which the games were released is that the PlayStation 3 and Xbox 360 versions featured an anaglyph-based stereoscopic 3-D mode, and were packaged with two sets of 3-D glasses.

[10] Reviewers at GamesMaster claimed that they would be content should this 3D mode pave the way for the "future of games", but the addition does not seem to have caught on to the mainstream videogame industry, as of the 2020s.

[36][37][38][39][40][41][42] GameSpot said of the PlayStation 3, Wii, and Xbox 360 versions: "Fun combat and crafty puzzles make this a good companion to the blockbuster movie".