Heavily anticipated upon release, Get Rich or Die Tryin' debuted and peaked at number one on the Billboard 200, and has been certified nonuple platinum by the RIAA.

[11][12] After bringing in West Coast rapper and Aftermath signee, the Game in early 2004,[13] Spider Loc was also signed, around the time of Young Buck's Straight Outta Cashville release.

[18] In the same year, in conjunction with Mobb Deep's Infamous Records, the label signed both Nyce and 40 Glocc.

[21] Numerous slander songs then arose on the internet from both camps, with Young Buck being included on a track with former rival and ex-G-Unit member, Game.

In late 2009, 50 Cent's fourth album, Before I Self Destruct, was released; which featured a track entitled "So Disrespectful", which insulted his various rivals including Jay-Z and former G-Unit Records artists, Game and Young Buck.

In early January 2010, 50 Cent claimed that he was looking to sign new comedians and authors to the label, venturing outside the realm of recording artists.

[26] Atlanta Young Jack Thriller would be the first comedian signed to the label,[26] releasing a weekly "So Disrespectful," YouTube podcast.

He released five records aimed at 50 Cent, Tony Yayo, Lloyd Banks, G-Unit, and 40 Glocc.

[33] In August 2010, amidst the controversy surrounding Montana Fishburne's entrance into the adult film industry, co-porn star, Brian Pumper, released several rap songs shouting out 50 Cent, Lloyd Banks and Tony Yayo.

[37] Lloyd Banks later in September would confirm that Mobb Deep member, Havoc was in talks to negotiate a new contract for the group in terms of signing to the label.

On August 13, 2010, in an interview with MTV News, Lloyd Banks announced that G-Unit had signed a limited distribution deal with EMI in North America.

The distribution deal is "strictly with artists Lloyd Banks and Tony Yayo," as stated by 50 Cent in an interview.

In early March 2011, rapper Shawty Lo reported in an interview that he was in talks with the label about signing.

[46][47] In December 2011, 50 Cent signed Jersey Shore star, DJ Pauly D, to G-Note Records, to produce three of label's albums.

[51] In the years to follow, 50 Cent would continue to struggle to maintain a palatable working relationship with Interscope.

In a 2012 interview, he explained the reason for the discord: "The deal I gave them was so well-put-together for them that they were to receive $750,000 in advance on the next albums - each one of the artists.

Buck provided the update in a recent interview stating, "I'ma be honest with you, finally we're at a point where we're having some kind of negotiations with what they're going to be able to do for us at G-Unit.

In 2010, G-Unit launched a subsidiary label called G-Note Records, with a focus on R&B and Pop music.