He was among the paid musicians in San Petronio, Bologna, from 1636 to 1641, which possibly means that he received his musical education there.
He was a founding member of the Bolognese Accademia Filarmonica in 1666 and was elected its conductor in 1679.
He composed a Dixit Dominus for the annual celebration of the academy in San Giovanni in Monte on 4 July 1675.
In 1686 he served temporarily as maestro di cappella of San Giovanni in Monte, Bologna.
In addition to several operas, Tosi composed sacred music in the typical late 17th-century Bolognese style.