GBU-10 bombs (along with the balance of the Paveway series) are produced by defense contractors Lockheed Martin and Raytheon.

Lockheed Martin was awarded a contract to compete with Raytheon when there was a break in production caused by transferring manufacturing out of Texas.

On 14 February 1991, an air-to-air kill was scored by a GBU-10 when an F-15E Strike Eagle of the 335th Tactical Fighter Squadron hit an Iraqi Air Force Mil Mi-24 Hind.

The GPS/INS-equipped version of the GBU-10 produced by Raytheon is the GBU-50/B, also informally also known as the EGBU-10 (GPS/INS-enabled LGBs are frequently referred to as Enhanced GBUs or EGBUs).

So far, Raytheon-built Paveway II EGBUs have only been produced for export, and have been used in combat by the British Royal Air Force over Afghanistan and Iraq.