The 4T80E is a series of front wheel drive fully automatic transmissions from General Motors.

[3] The 4Txx family is an evolution of the original Turbo-Hydramatic 125 transverse automatic introduced in the 1980 model year "X" body.

[1] The 4T80-E is a hydramatic transmission and was developed for use with V8 front-wheel-drive cars, and at the time exclusively the Cadillac Northstar engine.

It reportedly cost 80% more than a similar GM 4T60 transmission and weighed 60 lb (27 kg) more.

It wasn't until 2004 that Pontiac got usage of this transaxle in the Bonneville GXP which employed a 275 horsepower version of the Northstar 4.6L V8.