GluN2A-short isoforms specific to primates can be produced by alternative splicing and contain 1281 amino acids.

NMDA channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning.

[8] Variants of the gene are associated with the protective effect of coffee on Parkinson's disease.

[11] Whole exome/genome sequencing has led to the discovery of an association between mutations in GRIN2A and a wide variety of neurological diseases, including epilepsy, intellectual disability, autism spectrum disorders, developmental delay, and schizophrenia.

[12] GRIN2A has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.