The NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning.

The NR2 subunit acts as the agonist binding site for glutamate, one of the predominant excitatory neurotransmitter receptors in the mammalian brain.

[6] NR2B has been associated with age- and visual-experience-dependent plasticity in the neocortex of rats, where an increased NR2B/NR2A ratio correlates directly with the stronger excitatory LTP in young animals.

[7] Engineered to overexpress GRIN2B in their brains, mice and rats exhibit improved mental function.

[8][9] GRIN2B has been shown to interact with: This article incorporates text from the United States National Library of Medicine, which is in the public domain.