In 2020, he portrayed JD Vance in the drama Hillbilly Elegy and in 2023, he began playing the title role in the Netflix action thriller series The Night Agent.

From 2010 until 2013, he maintained a regular role in the Showtime comedy series The Big C, portraying Adam Jamison, the son of the lead character played by Laura Linney.

[8] In September 2014 he joined the cast of Meg Ryan's directorial debut film Ithaca, alongside Tom Hanks.

[9] Basso also appeared in the courtroom drama film The Whole Truth (2016), directed by Courtney Hunt and starring Keanu Reeves and Renée Zellweger.

[11] In November 2021, he was set to lead the political conspiracy thriller series The Night Agent with Luciane Buchanan on Netflix, created by Shawn Ryan and based on the 2019 New York Times bestselling novel of the same name by author Matthew Quirk.