[4] Luna made his screen acting debut as Kristofer Rostropovich in the drama film Fall to Grace, which premiered at South by Southwest in March 2005.

[5] On stage in Austin, Luna has portrayed Sergei Maxudov in Black Snow (2009),[6] the title character in Orestes (2009),[7] and Clov in Endgame (2010).

[9] Luna then starred as the lead character, Nate Hitchins, in the drama film Dance with the One, which premiered at South by Southwest in March 2010.

[12] Luna next recurred as Miguel Gilb, a former lover of Taylor Kitsch's character, on the second season of the HBO anthology drama series True Detective, appearing in 3 episodes.

[15] He was then cast as Paco Contreras, a detective searching for a serial killer on the Sunset Strip, on the ABC crime drama series Wicked City.

[17] The following year, he starred as border patrol agent Lance Flores in the thriller film Transpecos, opposite Clifton Collins, Jr. and Johnny Simmons.

[25] In April 2021, it was announced that Luna will play Tommy Miller in the HBO television adaptation of The Last of Us opposite Pedro Pascal.