[2] Beginning in 1983, she alternated her studies and her teaching activity with the professional, making various contributions, first for different media in La Plata and Buenos Aires and then, in 1985, as editor at the national news agency Noticias Argentinas.

In June 1993 she published El Jefe, vida y obra de Carlos Saúl Menem,[3] a bestseller reissued 19 times.

Back in her home country, in 1995 she became Chief of the Political Section of Página/12 until 1997, when she founded and assumed direction of the weekly Trespuntos, where an interview with Alfredo Astiz was published.

During the first two years she was a member of the Commissions of Economic Development, Mercosur, and Employment Policies; Woman, Childhood, Adolescence and Youth; and Public Works and Services.

In March 2010, making use of her perspective, experience, and public commitment as an official and journalist, she turned over the result of an investigation carried out during more than two years of legislative work in her book El pibe.

Negocios, intrigas y secretos de Mauricio Macri, el hombre que quiere ser Presidente, also for Editorial Planeta.

In July 2011, she renewed her mandate as deputy, heading the list of the Nuevo Encuentro Front in its first electoral participation in the city as a political party after having achieved legal status in the district.

After Citizen's Unity's victory in the primary, she was presented as a second candidate for national deputy by the Autonomous City of Buenos Aires, being elected along with Daniel Filmus and Juan Cabandié,[9] consecrating Unidad Porteña as the top opposition party in percentage of votes (21.74%).

[10] In October 2021, the Casa Rosada announced Cerruti would be standing down from her seat in the Chamber of Deputies in order to be appointed the official spokesperson for the Presidency of Argentina.