[5] Born in Caracas, Venezuela, Gaby Espino is the daughter of a chemical engineer and a publicist.

She is the oldest of five children, she has a sister, Andreina, two paternal half-brothers, Gustavo and Mariano and a maternal half-sister, Nelly.

[11] During the filming of Mas Sabe el Diablo in 2009, Espino was linked to her co-star, Jencarlos Canela.

[13][14] In September 2011, Canela and Espino did a live chat over social networking site Twitter, where they confirmed they were in relationship and announced that they were expecting their first child together.

On August 26, 2014 both Canela and Espino confirmed on their official Facebook page that they have decided to put an end to their relationship.