As Galena Airport, it was used as a military transport base during World War II, facilitating the transit of lend-lease aircraft to the Soviet Union.

As Galena Air Force Station, it was used by the USAF during the Cold War as an interceptor base for aircraft patrolling the western areas of Alaska.

[citation needed] Edward G. Pitka Sr Airport covers an area of 1,250 acres (506 ha) at an elevation of 154 feet (47 m) above mean sea level.

[1] The airport also sports a ski-jump takeoff ramp at one end and provisions for arresting gear (see picture, ski jump at 07 end) at the other, a leftover from the Cold War years as Galena Air Force Base, as tactical aircraft required more landing and takeoff space than was available on the runway.

For the 12-month period ending December 31, 2022, the airport had 19,000 aircraft operations, an average of 52 per day: 68% general aviation, 16% scheduled commercial, 11% military, and 5% air taxi.